Skip to main content

Drug and Toxin-Induced Liver Injury in Children

The liver plays a crucial role in processing and breaking down various substances in the body, including medications, chemicals, and toxins. Because of this, it is particularly vulnerable to damage when these substances are ingested, injected, or inhaled. This damage can range from mild changes in liver function, which might not cause any symptoms, to severe liver failure, which can be life-threatening.

It’s essential to consider the possibility that a child’s liver issues might be linked to exposure to drugs or toxins at home, or even from a parent’s workplace. In some cases, liver injury might be the only sign of a reaction to a drug or toxin, while in others, it might be accompanied by symptoms affecting other parts of the body.

In hospitalized children, it can sometimes be difficult to tell if liver problems are due to the illness they are being treated for or if they are a side effect of the medications they are taking. Among the different drugs that can cause liver injury, acetaminophen (often found in pain relievers) is a common culprit. Additionally, antibiotics (which are used to treat infections) and medications affecting the brain and nervous system are frequently linked to liver damage in children.

Download PDF

Symptoms

  • Jaundice: A yellowing of the skin and eyes.
  • Fatigue: Excessive tiredness or lack of energy.
  • Abdominal pain: Especially on the right side, where the liver is located.
  • Nausea and vomiting: Persistent nausea or episodes of vomiting.
  • Dark urine: Urine may appear darker than usual.
  • Pale stools: Stools may become lighter in color.
  • Itchy skin: Itching without an apparent cause.
  • Swelling: In the abdomen or legs, due to fluid accumulation.

Causes

  • Medications:
  • Environmental Toxins:
  • Herbal Supplements:
  • Dietary Supplements:
  • Poisonous Plants and Mushrooms:
  • Genetic Factors:

Diagnosis

  • Medical History:
  • Physical Examination:
  • Blood Tests and Urine Tests:
  • Imaging Studies:
  • Liver Biopsy:

Treatment Options

  1. Stopping the Offending Substance
  2. Supportive Care: Hydration, medications, nutrition
  3. Monitoring and Follow-up: Blood tests, imaging studies
  4. Advanced Treatments – Liver transplant

Why Choose Us

Expert team

Our pediatric specialists have extensive experience in treating children.

Personalized care

We create treatment plans that fit each child’s unique needs

Support and education

We teach children and families how to care for them and prevent future cases

Advanced treatments

Access to the latest treatments and products

Frequently Asked Questions

What is drug and toxin-induced liver injury?

Drug and toxin-induced liver injury (DILI) occurs when certain medications, chemicals, or substances cause damage to the liver. This condition can range from mild liver dysfunction to severe liver failure.

How can I prevent my child from developing liver injury?

Preventing liver injury involves careful monitoring of your child’s medication and supplement use, avoiding unnecessary exposure to environmental toxins, and consulting a healthcare provider before giving any new medication or supplement to your child.

How is drug-induced liver injury treated?

Treatment typically involves stopping the offending substance, providing supportive care, and monitoring the child’s liver function. In severe cases, advanced treatments like liver transplantation may be necessary.

Contact

Please feel free to contact us with any general or medical enquiry by calling us.

+254-709-529-000

+254-733-645-000

Primary Clinic Days

Monday - Saturday
8:00 am - 8:00 pm
Sundays & Public Holidays
9:00 am - 7:00 pm

Specialist Clinic Days

Monday - Saturday
8:00 am - 5:00 pm
Sunday
9:00 am - 5:00 pm