Waldenström's Macroglobulinemia

Overview

Waldenström’s Macroglobulinemia (WM) is a rare type of blood cancer that starts in the white blood cells called B lymphocytes. In WM, these cells produce too much of an antibody called IgM, leading to thickening of the blood and various health problems. While it’s more common in older adults, WM can occur in children and adolescents, though it’s extremely rare.

Symptoms

Common symptoms of WM include:

  • Fatigue and weakness
  • Easy bruising or bleeding
  • Frequent infections
  • Headaches and vision problems
  • Dizziness
  • Shortness of breath
  • Nosebleeds or bleeding gums
  • Swollen lymph nodes
  • Numbness or tingling in hands and feet

Causes

The exact cause of WM is unknown, but factors that may increase risk include:

  • Genetic mutations
  • Certain chronic infections
  • Exposure to certain chemicals or radiation
  • Family history of WM or related blood disorders

Diagnosis

To diagnose WM, our pediatric specialists may perform:

  • Blood tests to check for high levels of IgM and abnormal blood cells
  • Bone marrow biopsy to examine the bone marrow for cancer cells
  • Genetic testing to look for specific mutations associated with WM
  • Imaging tests like CT or MRI scans to check for enlarged lymph nodes or organs

Treatment Options

At Gertrude’s Children’s Hospital, we offer tailored treatments for WM, including:

  • Watchful waiting for asymptomatic cases
  • Targeted therapy with BTK inhibitors to slow cancer growth
  • Chemotherapy to destroy cancer cells
  • Immunotherapy to boost the immune system’s ability to fight cancer
  • Plasmapheresis to remove excess IgM from the blood
  • Stem cell transplantation for eligible patients

Patient Success Stories

At Gertrude’s Children’s Hospital, we are committed to providing the best possible care for children with Waldenström’s Macroglobulinemia. Here’s why families trust us:

“When our teenager was diagnosed with Waldenström's, we were shocked and scared. The team at Gertrude's Children's Hospital guided us through every step of the treatment process. Their expertise and compassionate care have given our child a chance at a healthy future.”

Davidfather of a WM patient

Living with Waldenström's Macroglobulinemia in children

WM is extremely rare in children. Our team has specialized experience in managing these uncommon cases.

While WM is a chronic condition, many patients respond well to treatment and can lead full lives. Our goal is to manage symptoms and prevent complications.

Pediatric WM treatment is tailored to the unique needs of growing children, considering factors like long-term effects on development and quality of life.

Contact Us

If your child has been diagnosed with Waldenström’s Macroglobulinemia or you’re seeking a second opinion, we’re here to help. Our expert team specializes in rare pediatric blood disorders and is committed to providing the best possible care.

Contact us today to schedule an appointment or learn more about our WM treatment program:

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